The Binding of Isaac: Four Souls Requiem is a huge expansion of the original Binding of Isaac: Four Souls game. Fight new monsters, collect new items, play as new characters. The expansion also adds new Solo and Multiplayer game modes and a brand new ROOM deck! The Room deck shakes up game play by adding global effects to all players that modify existing mechanics and even add new ones.

The Game includes:
- 61 Room Cards for Advanced Play
- 54 Loot Cards
- 50 Treasure Cards
- 54 Monster Cards
- 5 Bonus Souls for Advanced Play
- 22 Character Cards and 22 Starting Items